For any serious designer or programmer, it's very difficult to function without a multiple monitor setup.
Because often you need Webflow or your Programming environment full-screen and unobstructed while you are simultaneously testing, and reading documentation in a second window.
Even writing emails, watching instructional videos, or researching while you write a blog... all of these will be radically improved when you can have side-by-side views.
Tips;
That said, whatever you choose, your brain can adapt to the situation. Of the above, consistency of color and brightness are the most important factors.